. 2025 Jan 17;19(4):4011–4038. doi: 10.1021/acsnano.4c09566

Table 2. Globally Marketed Nanotechnology-Based Drug Formulations Approved by Regulatory Agencies such as the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Others^{8,15,87,184,206−211}.

Nano-DDS type	Formulation name	Active ingredient(s)	Company	Indication(s)
Lipid-based nanomedicine
Liposome	DaunoXome²¹²	Daunorubicin citrate	Galen	HIV-associated Kaposi’s sarcoma
Liposome	Myocet²¹³	Doxorubicin citrate, anthracycline cytotoxic agent	Teva Pharmaceutical Industries	Metastatic breast cancer
Liposome	Visudyne²¹⁴	Verteporfin	QLT PhotoTherapeutics	Severe eye conditions: macular degeneration, decreased vision, ocular histoplasmosis, pathologic myopia
Liposome	DepoDur²¹⁵	Morphine sulfate	Endo Pharmaceuticals	Postoperative analgesia
Liposome	Mepact²¹⁶	Mifamurtide	Takeda France SAS	High grade nonmetastatic osteosarcoma and myosarcoma
Liposome	Lipodox²¹⁷	Doxorubicin hydrochloride	Sun Pharmaceutical Industries (SPIL)	Kaposi’s sarcoma, ovarian cancer, multiple myeloma
Liposome	Lipusu²¹⁸	Paclitaxel	Luye Pharma	Lung squamous cell carcinoma
Liposome	Vyxeos²¹⁹	Daunorubicin and Cytarabine	Jazz Pharmaceuticals	Acute myeloid leukemia
Unilamellar liposome	AmBisome²²⁰	Amphotericin B	NeXstar Pharmaceuticals	Fungal infections; aspergillosis, candidiasis, cryptococcosis infections
PEGylated liposome	Doxil^221,222	Doxorubicin hydrochloride	Johnson & Johnson	Ovarian cancer, HIV-associated Kaposi’s sarcoma, multiple myeloma
PEGylated liposome	Caelyx²²³	Doxorubicin hydrochloride	Janssen Pharmaceuticals	Breast cancer, ovarian cancer, AIDS-related Kaposi’s sarcoma
PEGylated liposome	Onivyde²²⁴	Irinotecan	Merrimack Pharmaceuticals	Metastatic pancreatic cancer
PEGylated cationic lipid NP	mRNA-1273 vaccine²²⁵	mRNA vaccine	Moderna	COVID-19 infection vaccine
PEGylated cationic lipid NP	Onpattro²²⁶	Patisiran sodium	Alnylam Pharmaceuticals	Polyneuropathy of hereditary transthyretin-mediated amyloidosis
PEGylated cationic lipid NP	BNT162b2 vaccine²²⁵	mRNA vaccine	Pfizer	COVID-19 infection vaccine
Pulmonary surfactant	Curosurf²²⁷	Pulmonary surfactant	Chiesi Farmaceutici	Respiratory Distress Syndrome (RDS)
Nanoemulsion	Diprivan²²⁸	Propofol	AstraZeneca	Anesthetic agent for sedation of patient under critical carer
Lipid suspension, DMPC & DMPG	Abelcet²²⁹	Amphotericin B	Liposome Co.	Aspergillosis, invasive fungal infections
Micelle	Apealea²³⁰	Paclitaxel	Oasmia Pharmaceutical	Ovarian cancer, peritoneal cancer, fallopian tube cancer
Polymer-based nanomedicine
PEGylated protein	Adagen²³¹	Adenosine deaminase	Enzon Pharmaceuticals	Adenosine deaminase-severe combined immunodeficiency disorder
PEGylated protein	Oncaspar²³²	l-Asparaginase	Enzon Pharmaceuticals	Acute lymphoblastic leukemia
PEGylated protein	PEGintron²³³	PEGylated interferon α-2B	Merck & Co	Hepatitis
PEGylated protein	Neulasta²³⁴	Filgrastim	Amgen	Neutropenia
PEGylated protein	Pegasys²³⁵	PEGylated interferon α-2A	Genentech	Hepatitis B and Hepatitis C
PEGylated protein	Somavert²³⁶	Recombinant HGH receptor antagonist	Pfizer	Acromegaly
PEGylated protein	Mircera²³⁷	Epoetin beta	Vifor Pharma	Renal anemia
PEGylated protein	Cimiza²³⁸	Certolizumab pegol	UCB	Rheumatoid arthritis, Crohn’s disease, psoriatic arthritis, ankylosing spondylitis
PEGylated protein	Krystexxa²³⁹	Pegloticase	Savient Pharmaceuticals	Severe and treatment-refractory chronic gout
PEGylated protein	Plegridy²⁴⁰	Peginterferon β-1a	Biogene	Relapsing remitting multiple sclerosis
PEGylated protein	Adynovate²⁴¹	Recombinant antihemophilic factor	Baxalta US	Hemophilia A
GlycoPEGylated protein	Rebinyn²⁴²	Recombinant coagulation factor IX	Novo Nordisk	Hemophilia B
Nanoemulsion	Restasis²⁴³	Cyclosporine	Allergan	Chronic dry eye
Nanoemulsion	Estrasorb²⁴⁴	Estradiol hemihydrate	Novavax	Moderate to severe vasomotor symptoms in postmenopausal women
PEGylated aptamer	Macugen²⁴⁵	Pegaptanib sodium	Pfizer	Wet age-related macular degeneration
Polymeric micelle	Genexol-PM²⁴⁶	Paclitaxel	Lupi	Breast cancer
Polymeric (PLGA) microspheres	Zilretta²⁴⁷	Triamcinolone acetonide	Flexion Therapeutics	Knee osteoarthritis
Nanocrystals
Nanocrystal	Avinza²⁴⁸	Morphine	King Pharma	Chronic pain
Nanocrystal	Ritalin LA²⁴⁹	Methylphenidate hydrochloride	Novartis	Attention deficit hyperactivity disorder in children
Nanocrystal	Zanaflex²⁵⁰	Tizanidine hydrochloride	Acorda	Muscle relaxant
Nanocrystal	Emend²⁵¹	Aprepitant	Merck & Co	Antiemetic
Nanocrystal	Tricor²⁵²	Fenofibric acid	Abott Laboratories	Antihyperlipidemic
Nanocrystal	NanOss²⁵³	Hydroxyapatite	RTI Surgical	Bone substitute
Nanocrystal	Megace ES²⁵⁴	Megestrol acetate	Par Pharmaceuticals	Anorexia, cachexia and AIDS-related weight loss
Nanocrystal	IVEmend²⁵⁵	Fosaprepitant dimeglumine	Merck & Co	Antiemetic
Nanocrystal	Focalin XR²⁵⁶	Dexmethylphenidate hydrochloride	Novartis	Attention deficit hyperactivity disorder in children
Nanocrystal	Invega²⁵⁷	Paliperidone palmitate	Janssen Pharmaceuticals	Schizophrenia
Nanocrystal	Ryanodex²⁵⁸	Dantrolene sodium	Eagle Pharmaceuticals	Malignant hypothermia
Nanocrystal	Ostim²⁵⁹	Hydroxyapatite	Heraeus Kulzer	Bone substitute
Nanocrystal	EquivaBone²⁶⁰	Hydroxyapatite	Zimmer Biomet	Bone substitute
Nanocrystal	Vitoss²⁶¹	Calcium phosphate	Stryker	Bone substitute
Nanocrystal	Rapamune²⁶²	Sirolimus	Wyeth Pharmaceuticals	Immunosuppressant
Inorganic NPs
Iron NP	DexFerrum²⁶³	Iron dextran	American Regent	Iron deficiency in chronic kidney disease
Iron NP	Venofer²⁶⁴	Iron sucrose	Luitpold Pharmaceuticals	Iron deficiency in chronic kidney disease
Iron NP	Ferrlecit²⁶⁵	Sodium ferric gluconate	Sanofi	Iron deficiency anemia
Iron NP	INFed²⁶⁶	Iron dextran	Allergan	Iron deficiency anemia
Hafnium oxide NP	Hensify²⁶⁷	Hafnium oxide	Nanobiotix	Locally advanced squamous cell carcinoma
Iron oxide NP	Combidex²⁶⁸	Iron oxide	AMAG Pharmaceuticals	Magnetic resonance lymphography
Superparamagnetic iron oxide NP	Resovist²⁶⁹	Iron oxide	Bayer Schering Pharma	MRI imaging of liver lesions
Gadolinium NP	Primovist²⁷⁰	Gadoxetate	Bayer Schering Pharma	MRI imaging of liver lesions
Superparamagnetic iron oxide NP	Endorem²⁷¹	Iron oxide	Guerbet	MRI imaging of liver lesions
Core–shell carbon-dot doped silica NP	C-Dots²⁷²	Cy5 fluorophore	Elucida Oncology	PET-optical dual-modality imaging
Protein-based NPs
Engineered fusion protein NP	Ontak²⁷³	Denileukin diftitox	Eisai Co.	Leukemia, T cell lymphoma
Albumin NP	Abraxane^274,275	Paclitaxel	Eli Lilly	Metastatic breast cancer

Table 2. Globally Marketed Nanotechnology-Based Drug Formulations Approved by Regulatory Agencies such as the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Others8,15,87,184,206−211.

Table 2. Globally Marketed Nanotechnology-Based Drug Formulations Approved by Regulatory Agencies such as the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Others^{8,15,87,184,206−211}.