| WO2023237788 |
2023 |
Cellvie
(Switzerland) |
Mitochondria as a targeted delivery platform |
A mitochondrion comprising payloads including nucleic acids,
polypeptides, drugs or a combination thereof, electrostatically attached
to the outer membrane of the mitochondrion, to provide a drug delivery
platform of notable efficiency |
| WO2020061367 |
2020 |
ModernaTX (USA) |
Compounds
and compositions for intracellular delivery of therapeutic
agents |
Preparation of novel lipids and their NP compositions
useful
in delivery of therapeutic and/or prophylactic treatments such as
RNA, with improved endosomal escape and sustained efficiency and safety |
| WO2023144127 |
2023 |
AGS
Therapeutics (France) |
Extracellular vesicles from microalgae,
their biodistribution
upon administration, and uses |
DDSs containing extracellular
vesicles from microalgae loaded
with bioactive cargo, administered by a variety of routes, with applications
as therapeutics, including as vaccines, as anticancer therapeutics,
and as therapeutics for psychiatric diseases |
| US20120040397 |
2012 |
Cornell University
(USA) |
Photo-cross-linked nucleic acid hydrogels |
Methods and compositions for producing hydrogel nucleic acid
structures using photo-cross-linking, and using these hydrogels for
cell-free protein production, and for encapsulating and delivering
compounds |
| WO2013086373 |
2013 |
Alnylam Pharmaceuticals (USA) |
Lipids for the
delivery of nucleic acids |
Novel cationic lipids that
can be used in combination with
other lipid components such as cholesterol and PEG-lipids to form
lipid NPs with oligonucleotides, to facilitate the cellular uptake
and endosomal escape, and to knockdown target mRNA |
| WO2021077066; WO2021077067 |
2021 |
University of Pennsylvania (USA) |
Lipid nanoparticles
and formulations thereof for CAR mRNA delivery |
Lipid
NPs for delivery of mRNAs encoding chimeric antigenic
receptor (CAR), nucleic acid, and/or therapeutic agents to selected
target cells |
| WO2011076807 |
2011 |
Novartis (Switzerland) |
Preparation of cationic
and stealth lipids and compositions
for drug delivery |
Compositions comprising cationic lipids,
stealth lipids, and
helper lipids and optimization protocols for delivery of therapeutically
effective amounts of active agents to liver, tumors, and/or other
cells or tissues |
| WO2021030776 |
2021 |
Codiak Biosciences (USA) |
Extracellular
vesicle-antisense oligonucleotide constructs
targeting STAT6 and use for treating disease |
Exosomes,
comprising an antisense oligonucleotide with a contiguous
nucleotide sequence complementary to a nucleic acid sequence within
a STAT6 transcript, as well as methods for producing the exosomes
and using them to treat and/or prevent diseases |
| US20060040286 |
2006 |
Nanosphere (USA) |
Utilizing reporter oligonucleotides as bio-barcodes for detection
of target analytes and diagnostic uses |
Screening methods
and kits for detecting the presence or absence
of one or more target analytes, e.g., proteins, such as antibodies,
nucleic acids, or other compounds in a sample; in particular, reporter
oligonucleotides are used as biochemical barcodes for detecting multiple
protein structures in a solution |
| WO2018227012 |
2018 |
Massachusetts Institute of Technology (USA) |
Polymer–lipid materials for delivery of nucleic acids |
NPs comprising a conjugated polyethylenimine polymer (conjugated
lipomer) and a lipid–PEG conjugate, useful for the delivery
of active agents, for the treatment of disease |
| WO2022159855 |
2022 |
Johns Hopkins University
(USA) |
Photo-cross-linked bioreducible polymeric nanoparticles
for
enhanced RNA delivery |
Photo-cross-linked bioreducible
NPs for stable siRNA encapsulation
in high serum conditions, shielded surface charge, efficient intracellular
trafficking, and triggered cytosolic RNA release, allowing robust
siRNA-mediated knockdown in cancer cells and systemic siRNA delivery
to tumors in lungs |
| WO2021119402 |
2021 |
Harvard College (USA) |
Compositions
and methods for light-directed biomolecular barcoding |
Compositions and methods for nucleic acid barcoding that can
be used to linearly, combinatorially, or spatially barcode a plurality
of targets in a sample, as well as a device for use in a barcoding
method comprising a light source and a sample holder |
| WO2023092040 |
2023 |
Northwestern
University (USA) |
Spherical nucleic acids for cgas-sting
and stat3 pathway modulation
for the immunotherapeutic treatment of cancer |
Spherical
nucleic acids: nanostructures comprising a NP core
and a shell of oligonucleotides attached to the external surface of
the NP core, the oligonucleotide shell comprising a double-stranded
or single-stranded stem–loop DNA oligonucleotide activating
cyclic GMP–AMP synthase |
| WO2012110636 |
2012 |
Instituto Nacional de Investigacion y Tecnologia
Agraria y
Alimentaria (Spain) |
Carrier peptides for cell delivery |
Delivery of molecules into cells, using peptide binding proteins
from the cell microtubule motor complex, preferably dynein-binding
peptides, as carrier/delivery peptides; or functionalized structures,
such as NPs, linked to said peptides, for use in diagnosis, therapy,
and pharmacology |
| WO2005116226 |
2005 |
Midatech; Consejo Superior de Investigaciones
Cientificas (Spain) |
Magnetic nanoparticles comprising
metals and semiconductor
atoms conjugated to siRNA or microRNA for diagnosis and therapy of
diseases |
Magnetic NPs having a core comprising metals
and semiconductor
atoms conjugated to siRNA or microRNA for diagnosis and therapy of
diseases, for targeted transcriptional gene silencing, for targeted
mRNA degradation, for imaging mRNA, as a tool in functional genomics |
