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A, Southern blot of patient (P) and control (C) genomic DNA probed with a PCR product corresponding to nucleotides 9529–10112 of clone RP11-83I24. Aberrant fragments specific to patient DNA (black arrows) in HincII (left) and EcoRI (right) digests correspond to sizes of ∼10 kb and ∼1 kb, respectively. B, Sequence of the breakpoint region indicating (in large type) the three nucleotides common to both chromosome X and chromosome 7.
