Table 2.
Haplotype Interactions that Predispose to Type 1 Diabetes
|
Cases |
Controls |
|||||
| Block Pair/Chromosomal Locationor Variant Pair/Gene Paira | P Value | q Value | Z Score | P Value | q Value | Z Score |
| (1,4)/(1,4) | .000 | .000 | −2.9732 | .40 | .13 | −.133 |
| (V44:V45)/(NPPA:ADD1) | .01 | −3.4988 | .964 | 1.0808 | ||
| (1,10)/(1,12) | .000 | .000 | −3.5908 | .22 | .1 | −.712 |
| (V62:V46)/(SELE:SCNN1A) | .032 | −5.8305 | 1.00 | .3251 | ||
| (1,15)/(1,19) | .000 | .000 | −3.7758 | .60 | .18 | .243 |
| (V43:V17)/(NPPA:APOE) | .018 | −3.2417 | .93 | .3975 | ||
| (2,7)/(2,7) | .31 | .12 | −.4364 | .01 | .019 | −2.4063 |
| (V8:V39)/(APOB:NOS3) | .35 | −.2049 | .002 | −3.7312 | ||
| (2,8)/(2,8) | .03 | .036 | −2.0210 | .20 | .10 | −.709 |
| (V9:V22)/(APOB:LPL) | .002 | 2.3361 | 1.00 | −.9950 | ||
| (2,12)/(2,15) | .032 | .037 | −2.2290 | .59 | .18 | .315 |
| (V8:V20)/(APOB:LIPC) | .6 | .4021 | .022 | −2.2037 | ||
| (3,15)/(3,19) | .258 | .11 | −.6140 | .00 | .000 | −4.380 |
| (V41:V16)/(AGTR1:APOE) | .528 | .1457 | .0475 | −2.1793 | ||
| (5,7)/(5,7) | .22 | .10 | −.9170 | .000 | .000 | −2.2606 |
| (V50:V38)/(ADRB2:NOS3) | .37 | −.3814 | .01 | −2.7346 | ||
| (6,7)/(6,7) | .01 | .017 | −2.4328 | .30 | .12 | −.6584 |
| (V4:V26)/(LPA:PON1) | .0075 | −3.1221 | .996 | 1.3345 | ||
| (V4:V37)/(LPA:NOS3) | .016 | −3.0343 | .968 | .7989 | ||
| (V4:V39)/(LPA:NOS3) | .636 | .5031 | .046 | −2.6121 | ||
| (V65:V38)/(TNF:NOS3) | .014 | −2.5465 | .85 | 1.0279 | ||
| (V68:V37)/(TNFb:NOS3) | .01 | −3.6194 | .222 | −.6165 | ||
| (6,16)/(6,21) | .45 | .15 | −.4934 | .000 | .000 | −2.0156 |
| (V32:V35)/(TNFb:CBS) | .61 | −.2664 | .0375 | −4.2425 | ||
| (7,9)/(7,11) | .21 | .10 | −.9432 | .000 | .000 | −2.9033 |
| (V38:V7)/(NOS3:APOA4) | .16 | −1.6673 | .000 | −11.3963 | ||
| (V26:V7)/(PON1:APOA4) | .37 | −.3737 | .025 | −2.3077 | ||
| (V25:V10)/(PON1:APOC3) | .51 | −.0683 | .028 | −2.4287 | ||
| (V25:V12)/(PON1:APOC3) | .78 | .8031 | .028 | −2.1233 | ||
| (V38:V11)/(NOS3:APOC3) | .786 | .6522 | .004 | −3.5639 | ||
| (V37:V11)/(NOS3:APOC3) | .78 | .6673 | .028 | −2.6518 | ||
| (V37:V10)/(NOS3:APOC3) | .296 | −.4199 | .002 | −4.8354 | ||
| (V37:V12)/(NOS3:APOC3) | .73 | .7839 | .000 | −4.7122 | ||
| (V38:V13)/(NOS3:APOC3) | .71 | .4653 | .024 | −3.3368 | ||
| (9,13)/(11,16) | .02 | .027 | −2.3164 | .19 | .1 | −.7887 |
| (10,12)/(12,15) | .155 | .09 | −.9611 | .01 | .019 | −2.5475 |
| (V47:V20)/(SCNN1A:LIPC) | .172 | −1.1070 | .002 | −4.7115 | ||
| (14,16)/(17,21) | .000 | .000 | −4.1709 | .59 | .18 | .1466 |
| (V40:V45)/(DCP1:CBS) | .025 | −4.0039 | .697 | .7439 | ||
a
Block pairs/chromosomal locations are given in the format “(1,4)/(1,4),” and variant pairs/gene pairs are given in the format “(V44:V45)/(NPPA:ADD1).”