Skip to main content
. 2003 Nov 19;73(6):1444–1451. doi: 10.1086/380207

Figure 1.

Figure 1

The sequence of SVA retrotransposition events. A full-length SVA element of unknown origin retrotransposed into the empty-site sequence on chromosome 4, represented on contigs AC037439 and AC068352. During subsequent transcription of the new SVA at this site, the SVA poly A was bypassed in favor of a downstream poly A, producing the first transduction event. The full-length SVA and transduction 1 inserted into a new genomic location at target site 2 on chromosome 3 to produce the sequence found in contig AC016142. During subsequent transcription of the new SVA on chromosome 3, both the SVA poly A and the poly A from transduction 1 were bypassed in favor of a poly A farther downstream, producing the second transduction event. The transcript containing a full-length SVA element and both transduction events inserted into target site 3 on chromosome 1, which is in exon 5 of the α-spectrin gene. However, the integration process resulted in a structure that was 5′ truncated and inverted compared with the precursor, a common process in L1-mediated retrotransposition. RNA is represented by a dashed line; DNA is represented by a solid line.