Fig. 1.

GNC–PTEN complexes can effectively inhibit the proliferation, migration, and invasion of hepatoma cells in vitro. a,b MTT proliferation assay of HepG2 cells and SMMC-7721 cells after incubating with different reagents, respectively. The blue line, red line, green line, and black line represent the negative control group, PTEN group (PTEN, 2 ng/µl), in situ synthetic GNCs (HAuCl₄, 0.68 ng/µl), and in situ GNC–PTEN complex group (PTEN, 2 ng/µl; HAuCl₄, 0.68 ng/µl), respectively. c The left and right sides are the representative results of scratch healing experiment of HepG2 cells and SMMC-7721 cells after incubating with different reagents, respectively. The statistical results are in the middle. At each point in time, three fields of photographs were randomly selected, and the picture was 100×. d. Transwell invasion experiments of HepG2 and SMMC-7721 after incubating with different reagents, respectively. The representative results (100×) are shown in the graph. The statistical results of c and d were completed by imageJ. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; NS no significant statistical significance