Table 2.
Relationship between CT/MR imaging and 18F-FDG PET/CT results and neck histopathology findings
| Imaging | No. patients | Percentage (95% confidence interval) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| TP | FP | FN | TN | Sensitivity | Specificity | Accuracy | PPV | NPV | |
| Patients (n = 178) | |||||||||
| CT/MR | 15 | 15 | 27 | 121 | 35.7 (21.6–52.0) | 89.0 (82.5–93.7) | 76.4 (69.5–82.4) | 50.0 (34.8–65.2) | 81.8 (78.0–85.0) |
| PET/CT | 29 | 30 | 13 | 106 | 69.1 (52.9–82.4) | 77.9 (70.0–84.6) | 75.8 (68.9–81.9) | 49.2 (39.9–58.5) | 89.1 (83.7–92.8) |
| P value* | 0.001 | 0.003 | 1.000 | ||||||
| Neck sides (n = 199) | |||||||||
| CT/MR | 16 | 16 | 28 | 139 | 36.4 (22.4–52.2) | 89.7 (83.8–94.0) | 77.9 (71.5–83.5) | 50.0 (35.3–64.7) | 83.2 (79.8–86.2) |
| PET/CT | 31 | 33 | 13 | 122 | 70.5 (54.8–83.2) | 78.7 (71.4–84.9) | 76.9 (70.4–82.6) | 48.4 (39.6–57.3) | 90.4 (85.5–93.7) |
| P value† | < 0.001 | 0.001 | 0.880 | ||||||
| Neck levels (n = 678) | |||||||||
| CT/MR | 17 | 20 | 41 | 600 | 29.3 (18.1–42.7) | 96.8 (95.1–98.0) | 91.0 (88.6–93.1) | 46.0 (32.1–60.5) | 93.6 (92.5–94.5) |
| PET/CT | 36 | 67 | 22 | 553 | 62.1 (48.4–74.5) | 89.2 (86.5–91.5) | 86.9 (84.1–89.3) | 35.0 (28.4–42.1) | 96.2 (94.8–97.2) |
| P value† | < 0.001 | < 0.001 | 0.003 | ||||||
FN false negative, FP false positive, NPV negative predictive value, PPV positive predictive value, TN true negative, TP true positive
*McNemar test
†Logistic regression using GEE (Generalized Estimating Equations) that accounted for the clustering of observations within patients