Fig. 4.

RNA-seq analysis of SBC3 and SBC5. a The heatmap represented the high expression of the top 35 genes in SBC5, comparing with SBC3, each with three replicates. b GO enrichment analysis of up-regulated genes in SBC5 (top 20). Ordinate is the enriched GO, including molecular function, biological process, and cellular component. Abscissa is rich factor in which different colors of the nodes represent different FDR(p value_corrected), whereas different node size representes the number of genes enriched in the category. c KEGG analysis of up-regulated genes in SBC5 (Top 20). Ordinate is the enriched pathway of the up-regulated genes. Abscissa is rich factor in which different colors of the nodes represent different FDR (p value_corrected) whereas different node size representes the number of genes enriched in the pathway. The above RNA-seq data a–c were analyzed on the free online platform of Majorbio I-Sanger Cloud Platform (https://www.i-sanger.com). d Gene co-expression of S100A8 and S100A9 in lung cancer patients from TCGA data.Data was obtained and analyzed in https://www.oncomine.com. Data of KM survial plot of S100A8 (e) and S100A9 (f) were obtained and analyzed using the free platform (https://kmplot.com), Affymatrix ID: 202917_s_at, 203535_at