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. 2025 Jan 28;122(5):e2416089122. doi: 10.1073/pnas.2416089122

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Copyright © 2025 the Author(s). Published by PNAS.

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Fig. 6. — LE-specific disruption of RAR signaling leads to LE metaplasia. (A and B) H&E staining of PD 90 DN/+^Ltf and DN/DN^Ltf uteri. Insets show gross morphology of the entire FRTs upon dissection, note that the uterine horns are visually thicker. (C and D) IF staining of basal marker TRP63 (green, arrows) and uterine gland marker FOXA2 (red, open arrow). Epithelia outlined with dotted lines; l, lumen; g, glands. (E and F) IF staining of epithelial marker CDH1 (green) and stratified epithelial marker KRT5 (red). (G and H) IF staining of macrophage marker F4/80 (red, arrows). Note that there is macrophage infiltration into the stratified epithelium of the DN/DN^Ltf uteri (H, arrows). (I) Quantitative RT-PCR of indicated genes comparing PD 90 control (CTRL), DN/+^Ltf, and DN/DN^Ltf uterine tissues. Error bars represent mean with SD.