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. 2020 Feb 7;146(5):1205–1215. doi: 10.1007/s00432-020-03145-6

Fig. 1.

Fig. 1

Selection of candidate CRC-related miRNAs through bioinformatics analysis of TCGA database. a PCA analysis showed correct differentiation of normal data from tumor data

adopted from TCGA database. b Drawn heat map for the top 20 miRNAs which are differentially expressed in normal and tumor CRC samples using heatmap2 package in R programing. c Target predictions of 10 candidate miRNAs. The MAPK and TGFβ signaling were the major pathways to be targeted by candidate miRNAs