Table 2.

Summary of the physiological and pathological activities of AID with select references

Physiological involvement of AID	References	Pathological Involvement of AID	References
Somatic hypermutation and Class switch recombination	Muramatsu et al. (2000); Petersen-Mahrt et al. (2002)	c-MYC/IGH translocation in BL	Ramiro et al. (2004); Robbiani et al. (2008); Takizawa et al. (2008)
DNA demethylation during B-cell maturation	Dominguez et al. (2015)	Deregulation by EBV in lymphomas	Epeldegui et al. (2007a, b); Heath et al. (2012); Kim et al. (2013); Kalchschmidt et al. (2016); Grande et al. (2019)
Cell reprogramming (oocyte and pluripotent stem cells)	Morgan et al. (2004); Rai et al. (2008); Popp et al. (2010)	Malaria driven deregulation in eBL	Torgbor et al. (2014); Robbiani et al. (2015)
		HIV-associated NHL through deregulation by HIV proteins	Wang et al. 2018; Sall et al. (2019)
		Gene deregulation in DLBCL	Lohr et al. (2012); Álvarez-Prado et al. (2018); Chapuy et al. (2018)
		Methylation heterogeneity in DLBCL	Teater et al. (2018)
		Involvement in inflammation related cancers	Munoz et al. (2013); Nonaka et al. (2016); Li et al. (2019)