Table 3.

Univariate and multivariate survival analysis

		Univariate analysis			Multivariate analysis
		HR	95% CI	p value	HR	95% CI	p value
Progression-free survival (PFS)
Age	Per year	0.973	0.925–1.024	0.296
Gender	Male vs female	0.454	0.192–1.075	0.073
ECOG at the first restaging	0 vs ≥ 1	0.414	0.158–1.081	0.072
Smoking	Never/smokers	1.897	0.551–6.539	0.310
Line of treatment	0 or 1 vs ≥ 2	1.129	0.470–2.712	0.786
Tumor PD-L1	Neg vs pos	0.882	0.268–2.906	0.836
Histology	Adeno vs other	0.954	0.399–2.280	0.915
Post-SUVmax	< 12.7 vs ≥ 12.7	0.489	0.188–1.276	0.144
Post-SUVmean	< 5.6 vs ≥  5.6	0.425	0.162–1.116	0.082
Post-MTV	< 91.3 vs ≥  91.3	0.257	0.095–0.696	0.008
Post-TLG	< 541.5 vs ≥  541.5	0.257	0.095–0.696	0.008	0.295	0.107–0.817	0.019
Post-NLR	< 4.9 vs ≥ 4.9	0.262	0.100–0.687	0.006	0.257	0.095–0.696	0.019
Overall survival (OS)
Age	Per year	0.985	0.937–1.037	0.570
Gender	Male vs female	0.354	0.130–0.964	0.042
ECOG at the first restaging	0 vs ≥ 1	0.175	0.050–0.613	0.006	0.091	0.016–0.510	0.006
Smoking	Never/smokers	2.321	0.633–8.508	0.204
Line of treatment	0 or 1 vs ≥ 2	1.415	0.555–3.603	0.467
Tumor PD-L1	Neg vs pos	0.033	0.574–5.446	0.642
Histology	Adeno vs other	0.714	0.281–1.813	0.479
Post-SUVmax	< 12.7 vs  ≥  12.7	0.506	0.183–1.403	0.191
Post-SUVmean	< 5.6 vs ≥  5.6	0.403	0.136–1.192	0.100
Post-MTV	< 91.3 vs ≥  91.3	0.194	0.058–0.646	0.008
Post-TLG	< 541.5 vs ≥  541.5	0.194	0.058–0.646	0.008	0.204	0.042–0.988	0.041
Post-NLR	< 4.9 vs  ≥  4.9	0.135	0.043–0.428	0.001	0.044	0.007–0.275	0.001