Table 2.
Secondary efficacy outcomes (FAS)
| Secondary Efficacy Outcomes | Low-dose group | High-dose group | Control group |
|---|---|---|---|
| mRS ≤ 2 on D90, no./total no. (%) | 68/85 (80.0%) | 55/67 (82.1%) | 52/68 (76.5%) |
| NIHSS score improvement of ≥ 4 points or recovery to ≤ 1 point (NIHSS 0–1, no./total no. (%)) | |||
| D7 | 13/90 (14.4%) | 17/71 (23.9%) | 11/71 (15.5%) |
| D14 | 33/82 (40.2%) | 30/68 (44.1%) | 24/66 (36.4%) |
| D30 | 50/84 (59.5%) | 46/68 (67.6%) | 41/68 (60.3%) |
| D90 | 68/84 (81.0%) | 51/65 (78.5%) | 52/68 (76.5%) |
| Changes of NIHSS score from baseline, median (IQR) | |||
| D7 | −2.0 (−3.0 to −1.0) | −2.0 (−3.0 to −1.0) | −1.0 (−2.0 to 0.0) |
| D14 | −3.0 (−4.0 to −2.0) | −3.0 (−5.0 to −2.0) | −3.0 (−4.0 to −2.0) |
| D30 | −4.0 (−6.0 to −3.0) | −4.0 (−5.0 to −3.0) | −4.0 (−5.0 to −2.0) |
| D90 | −5.0 (−6.0 to −4.0) | −5.0 (−6.0 to −4.0) | −5.0 (−6.0 to −3.5) |
| BI score, median (IQR) | |||
| D7 | 60.0 (45.0–90.0) | 65.0 (45.0–85.0) | 65.0 (45.0–80.0) |
| D14 | 85.0 (60.0–95.0) | 85.0 (57.5–95.0) | 80.0 (60.0–95.0) |
| D30 | 95.0 (80.0–100.0) | 95.0 (77.5–100.0) | 90.0 (80.0–100.0) |
| D90 | 100.0 (90.0–100.0) | 100.0 (95.0–100.0) | 100.0 (90.0–100.0) |
| BI score ≥ 95, no./total no. (%) | |||
| D7 | 16/89 (18.0%) | 8/71 (11.3%) | 10/71 (14.1%) |
| D14 | 24/82 (29.3%) | 25/68 (36.8%) | 19/65 (29.2%) |
| D30 | 44/84 (52.4%) | 38/68 (55.9%) | 33/68 (48.5%) |
| D90 | 61/84 (72.6%) | 51/65 (78.5%) | 50/68 (73.5%) |
| MoCA, median (IQR) | |||
| D7 | 18.0 (13.0–23.0) | 21.0 (18.0–25.0) | 20.0 (14.0–23.0) |
| D14 | 21.0 (16.0–24.5) | 24.0 (19.0–26.0) | 22.5 (16.5–25.0) |
| D30 | 21.0 (14.0–25.0) | 24.0 (19.5–27.0) | 22.0 (16.5–26.0) |
| D90 | 23.0 (16.0–26.0) | 24.0 (20.0–28.0) | 22.0 (18.0–27.0) |
| SS-QOL, median (IQR) | |||
| D7 | 174.0 (147.5–195.5) | 173.0 (154.0–206.0) | 174.0 (138.0–200.0) |
| D14 | 194.0 (163.0–212.0) | 197.0 (172.0–224.0) | 196.0 (163.0–210.0) |
| D30 | 209.0 (188.0–226.5) | 212.0 (189.0–234.5) | 208.5 (185.0–223.0) |
| D90 | 220.0 (200.0–234.0) | 226.0 (201.0–239.0) | 225.5 (204.5–237.0) |
D7 indicates day 7; D14, day 14; D30, day 30; D90, day 90; IQR, interquartile range; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; BI, Barthel Index; MoCA, Montreal Cognitive Assessment Scale; and SS-QOL, Stroke Specific Quality of Life Scale.