Table 2.
Maternal ASM regimens of pregnancies exposed to brivaracetam, eslicarbazepine, lacosamide, and zonisamide.
| BRV | ESL | LCM | ZSN | |
|---|---|---|---|---|
| Exposed pregnancies (n,%) | 8 (23) | 8 (23) | 6 (17) | 12 (34) |
| Monotherapy (n, %) | 7 (88) | 4 (50) | 3 (50) | 5 (42) |
| Previous alternative ASM reported in clinical documentation (n, %) |
6 (75) |
2 (25) |
5 (83) |
5 (42) |
| Highest daily dose, mg (median, min–max) | 150 (50–175) | 800 (400–1600) | 350 (200–600) | 200 (150–400) |
| No. of concomitant ASMs (median, min–max) | 1 (1–3) | 2 (1–3) | 2 (1–3) | 2 (1–4) |
| Concomitant ASM (n, %) Levetiracetam Benzodiazepines* Other** |
0 1(13) 1 (13) |
2 (25) 3 (38) 1 (13) |
2 (33) 2 (33) 0 |
7 (58) 3 (25) 4 (33) |
| Therapeutic drug monitoring (n, %) | 3 (38) | 3 (38) | 4 (67) | 6 (50) |
| Folic acid in pregnancy (n, %) | 8 (100) | 5 (63) | 5 (83) | 12 (100) |
| Seizure activity in pregnancy (n, %) | 3 (37) | 4 (50) | 3 (50) | 7 (58) |
| Seizure activity postpartum (n, %) | 1 (13) | 1 (13) | 2 (33) | 1 (8) |
| GTC seizures (n, %) | 2 (25) | 3 (38) | 1 (17) | 4 (33) |
Abbreviations: ASM – antiseizure medicine, BRV – brivaracetam, ESL – eslicarbazepine, GTC – generalised tonic clonic, LCM – lacosamide, ZSN – zonisamide, IQR – interquartile range.
*Benzodiazepines include clobazam and clonazepam. **Other ASMs include lamotrigine, carbamazepine, pregabalin, and topiramate. > 1 concomitant ASM is possible.