Table 2.
Results of the Linkage Analysis Performed on Families with Sibs Affected by KA[Note]
|
LOD Score (% Information Content) in |
||||||
| Primary Scan |
Refined Map |
Conditional Analysis |
||||
| ChromosomalRegionand Marker | Single Point | Multipoint | Single Point | Multipoint | Single Point | Multipoint |
| 22q12: | ||||||
| D22S315 | .97 (61) | 1.54 (80) | 1.07 (64) | 1.77 (84) | … | … |
| D22S1167 | … | … | .56 (38) | 2.54 (81) | … | … |
| D22S1163 | … | … | .97 (56) | 2.44 (83) | … | … |
| D22S280 | 1.84 (59) | 2.90 (82) | 1.66 (56) | 3.50 (86) | … | … |
| D22S424 | … | … | .27 (34) | 2.40 (86) | … | … |
| D22S277 | … | … | .74 (72) | 1.64 (92) | … | … |
| D22S283 | .88 (87) | 1.09 (96) | 1.67 (84) | 1.67 (95) | … | … |
| 2q23-2q24: | ||||||
| D2S151 | .40 (73) | .44 (84) | .67 (66) | .72 (85) | 2.19 (70) | 2.27 (87) |
| D2S2275 | … | … | 1.89 (47) | 1.00 (87) | 2.85 (42) | 2.21 (88) |
| D2S2299 | … | … | 1.23 (57) | .99 (89) | 1.62 (63) | 1.75 (90) |
| D2S141 | … | … | 2.14 (66) | .86 (93) | 3.74 (72) | 2.29 (93) |
| D2S142 | 1.28 (71) | 1.45 (83) | 2.34 (70) | 1.23 (93) | 3.84 (71) | 2.27 (94) |
| D2S284 | … | … | .10 (50) | .93 (88) | .39 (50) | 2.06 (87) |
| D2S156 | … | … | .45 (65) | .95 (87) | 1.99 (69) | 2.07 (87) |
| D2S2330 | 1.27 (63) | 1.22 (82) | 2.01 (58) | 1.53 (81) | 1.78 (62) | 2.26 (81) |
| 2q35: | ||||||
| D2S2382 | 1.15 (68) | .97 (83) | .84 (69) | .79 (84) | 1.70 (68) | .95 (83) |
| 5′(CA)na | … | … | .60 (30) | .77 (84) | .17 (32) | .98 (58) |
| 469+14G/Ca | … | … | .21 (23) | .73 (84) | .38 (23) | 1.00 (84) |
| 1729+55 del4a | … | … | .38 (22) | .50 (86) | .37 (24) | .71 (87) |
| D2S1471 | .25 (64) | .31 (90) | .07 (69) | .18 (90) | .14 (70) | .50 (90) |
Note.— Linkage results are shown for markers of three chromosomal regions (22q12-q13, 2q23-q24, and 2q35) with LOD scores >0.83 (P<.025) in the primary screen of the genome conducted on a set of 38 families and for the whole family set (63 families). An analysis was performed on the 30 families displaying negative LOD scores at D22S280. Linkage analyses were performed using the MLB model-free method implemented in an extension of the Genehunter program.
a
NRAMP1 intragenic polymorphisms.