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. 2025 Feb 7;11(6):eado9751. doi: 10.1126/sciadv.ado9751

Table 2. Laboratory findings for controls, all patients with CO poisoning, and those with 1 month follow-up.

Comparisons among the control group, all patients with CO exposure, patients with follow-up results at 1 month and GDS = 1, and those where 1-month GDS was >1. Rows demonstrate age, % male, plasma GSN, flow cytometry results including MPs/μl, % of MPs expressing various protein markers specific to different cells including neutrophils (CD66b), endothelium (CD146), platelets (CD41a), and neutrophils (PMN) % expressing protein values above a minimum threshold for CD18, MPO, pGSN, and CD41a [indicative of platelet-neutrophil interaction as described previously (15)]. Data are mean ± SD. Statistical comparisons were made between control and all 150 patients with CO poisoning and values with P < 0.05 (t test) indicated by +, and between patients with good outcome versus neurological sequelae with P < 0.05 indicated by *. NS, not significant.

Control (n = 150) All CO (n = 150) CO-good (n = 65) CO-DNS (n = 33)
Age (years) 45.3 ± 16.3 47.9 ± 17.2 NS 44.4 ± 15.0 54.4 ± 19.4*
% Male 65.3 ± 47.8 65.3 ± 47.8 NS 63.2 ± 48.6 50.0 ± 50.8
pGSN (μg/ml) 178.1 ± 161.5 11.6 ± 11.7+ 13.4 ± 16.4 11.6 ± 6.8
MPs/μl 1100 ± 447 1423 ± 489+ 1485 ± 560 1431 ± 435
% CD66b 12.6 ± 5.8 16.6 ± 7.3+ 17.2 ± 0.9 16.3 ± 6.7
% CD146 26.4 ± 10.6 26.7 ± 8.8+ 27.0 ± 9.8 24.3 ± 7.5
% TSP 11.3 ± 4.5 13.6 ± 6.1+ 13.6 ± 5.8 14.0 ± 6.9
% CD41 6.8 ± 2.4 7.6 ± 7.6 NS 7.8 ± 7.8 7.0 ± 2.1
% TMEM 29.4 ± 4.5 31.5 ± 4.9+ 32.5 ± 4.7 30.5 ± 6.4
% F-actin 17.1 ± 2.0 20.3 ± 9.0 20.1 ± 4.5 20.3 ± 5.6
PMN % CD18 4.2 ± 5.2 7.2 ± 4.7+ 7.2 ± 5.0 6.6 ± 3.2
PMN % MPO 4.2 ± 3.8 8.4 ± 4.7+ 9.8 ± 5.0 9.0 ± 4.4
PMN % CD41 5.9 ± 4.2 9.6 ± 4.4+ 9.7 ± 3.8 10.2 ± 5.3
PMN % pGSN 5.0 ± 2.0 4.5 ± 2.9 NS 5.2 ± 3.3 4.6 ± 2.8