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. 2002 Feb;1(1):137–151. doi: 10.1128/EC.1.1.137-151.2002

FIG. 1.

FIG. 1.

New multigene family containing a hot spot for retroelement insertion. (A) Map of homologous cDNAs (cDNA-004, cDNA-005, cDNA-040, and cDNA-132 with accession numbers AF403385, AF403388, AF403386, and AF403387, respectively) isolated from a T. brucei AnTat1 library. The large and small black boxes represent coding and noncoding sequences, respectively, and the white box shows the 5" end of a non-LTR retrotransposon ingi. The 12-bp sequence upstream of the retrotransposon is shown below the cDNA-005 map. (B) Schematic map of the RHS genes and pseudogenes sequenced from five different cosmid clones of AnTat1 genomic DNA (Cos-02, -03, -12, -17, and -23 with accession numbers AY046893, AY046894, AY046896, AY046895, and AY046897S1, and AY046897S2, respectively). Coding and noncoding sequences are represented by large and small boxes, respectively. The black boxes correspond to sequences presenting at least 80% identity, while the hatched boxes correspond to unrelated sequences. Premature stop codons (S) and retroelement RIME (○) or ingi (•) insertion are indicated above the maps. The RIME and ingi retroelements inserted in the RHS pseudogene of Cos-12 and Cos-23 clones are shown below the maps. The 12-bp repetitive duplication sequences flanking the retroelements are shown below the RIME/ingi map.