Figure  4.

Kindlin-1 protein-domain organization. A, Schematic representation of the FERM, PH, and talin homology domains of kindlin. B, Amino acid sequence alignment between members of the human kindlin family and their C. elegans ortholog UNC-112. The overall amino acid sequence identity is high (41%) between the two species. C, Evolutionary tree analysis by UPGMA, showing that kindlin-1 and kindlin-2 are more related and more recently diverged from kindlin-3. Protein alignments and UPGMA analysis were performed by use of the Geneworks 2.5 analysis package (Oxford Molecular Group).