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. 2003 Jun 11;73(1):49–62. doi: 10.1086/376547

Table 1.

Characteristics of Bipolar Genome Scans[Note]

TotalNo. ofc
 No. with Diagnosisd
Study Site First Authora DiagnosticCriteriab Peds Aff Model1 Model2 Model3 BP-I SAB BP-II RUP Other No. of Markers No. ofEmptyBinse GeneticModel(s)f Type of Analysis OutputUsedg Ethnicityh
Very narrow analysis:
 NIMH Detera-Wadleigh1 R+D3R 97 424 264 336 424 232 32 72 88 355 3 NP Multipoint NPL NAm
 U.K./Irish Bennett2 D4 151 367 288 325 367 288 12 25 34 8 398 0 NP Multipoint MLS Ir+Br
 Columbia Liu3 R 39 297 115 208 297 101 14 93 89 333 0 D+R Two-point LOD NAm
 Finland) Ekholm4 D4 41 132 107 107 132 95 12 2 16 7 368 0 D+R Two-point LOD Finnish
 Sydney 1 Badenhop5 R 13 69 40 44 69 33 7 4 25 298 0 (4) Two-point LOD Eur (Aust)
 Sydney 2 Schofield6 R 15 63 41 46 63 31 10 5 17 382 0 (4) Two-point LOD Eur (Aust)
 Quebec Morissette7 D3R 5 56 42 42 56 39 3 5 9 314 0 D+R Two-point LOD Quebec isol
 Edinburgh Blackwood8 D3R 7 41 27 36 41 27 8 1 5 372 0 D+R Two-point LOD British
 Costa Rica McInnis9 D3R 2 24 24
 24 24 22
 2
 473 1 D Two-point LOD CR isol
  Total (Model 1) 948 868 80
Added for narrow analysis:
 Hopkins/Dana McInnis10 R 65 301 232 301 129 6 97 69 823 0 NP Multipoint NPL NAm
 Bonn Cichon11,i R+D3R 75 245 128 128 104 24 (23) 359 0 NP Multipoint NPL G+Is+It
 NIMH-IM Detera-Wadleigh12 R 22 160 118 160 64 18 36 42 584 0 NP Multipoint MLS NAm+OOA
 UCSD Kelsoe13 D3R 20 76 48 76 33 15 28 428 1 (3) Two-point LOD NAm
 UC London Curtis14,j R 7 74 39
 39 24
15
 (35) 365 0 Max Two-point/three-point LOD Br+Icelandic
  Total (models 1+2) 1,733 1,222 124 394
Added for broad analysis:
 Ottawa Turecki15 R 31 106 106 33 3 25 45 363 1 (5) Two-point LOD Eur (Can)
 Antwerp 1 Van Broeckhoven16 R 10 56 56 14 1 15 21 5 372 0 D+R Two-point LOD Belgian
 Utah Coon17 R 8 51 51 20 12 19 328 19 D Two-point LOD Eur
 Antwerp 2 Van Broeckhoven16  R 9 47 47
 22
 2
 6
 17
 361 0 NP Multipoint NPL Swedish
  Total (models 1+2+3)  2,437 1,311 130 452 524 20

Note.— Total number of pedigrees collected is shown here; the numbers included in the model 1 and 2 analyses are shown in figures 1 and 2.

a

Superscripts indicate references as follows: 1 = Detera-Wadleigh et al. (1997), Edenberg et al. (1997), Rice et al. (1997), and Stine et al. (1997); 2 = Bennett et al. (2002); 3 = Liu et al. (2003); 4 = Ekholm et al. (2002) and J.E., L.P., and J.Lö. (unpublished data); 5 = Badenhop et al. (2002); 6 = R.F.B., P.B.M., J.A.D., L.J.A., and P.R.S. (unpublished data) and Badenhop et al. (2002); 7 = Morissette et al. (1999); 8 = Blackwood et al. (1996) and D. Blackwood, W. Muir, D. Porteus, and S. Macgregor (unpublished data); 9 = McInnis et al. (1996); 10 = McInnis et al. (2003); 11 = Cichon et al. (2001); 12 = Detera-Wadleigh et al. (1999); 13 = Kelsoe et al. (2001); 14 = Curtis et al. (2003); 15 = Turecki et al. (2001); 16 = C.V., S.Cl., J.M., and R.A. (unpublished data); 17 = Coon et al. (1993).

b

R = RDC; D3R = DSM-IIIR; D4 = DSM-IV.

c

Peds = informative pedigrees; Aff = affected genotyped cases.

d

SAB = schizoaffective bipolar; RUP = recurrent major depressive (unipolar) disorder; Other = other mood disorder. Columns for Models 1 (BP-I+SAB), 2 (+BP-II) and 3 (+RUP) show the number of genotyped affected cases; additional columns show numbers for each diagnosis. Data from narrower models were carried over if the broader model was not available. For Bennett and Blackwood, SAB cases (highlighted in boldface italic type) were included in model 2 but not model 1 analyses. For Cichon, BP–not otherwise specified cases were judged equivalent to DSM-IV BP-II by the investigators and are listed as such here. “Other” diagnoses were distributed and handled as follows (included in model 3 analyses, because these cases were a small proportion of the study’s broadest analysis): from Bennett, eight BP–not otherwise specified; from Ekholm, three BP–not otherwise specified, two single-episode unipolar, and two cyclothymia; from Van Broeckhoven (Antwerp 1), five cyclothymia. Excluded from model 1 (included in model 4): from Cichon, 23 single-episode unipolar; from Curtis, 28 single-episode unipolar and RUP, and seven other mood disorders.

e

Number of bins with 0 markers.

f

NP = nonparametric, no model; D = dominant; R = recessive; max = maximized over parameters. Numbers in parentheses indicate the number of models tested.

g

LOD = parametric LOD score; MLS = maximum LOD score, ASP analysis.

h

Br = British; Eur = predominantly European descent; Ir = Irish; It = Italian; NAm= North American (predominantly European); Aust = Australian; CR = Costa Rican; G = German; Is = Israeli; Can = Canadian; OOA= Old Order Amish isolate; isol = genetic isolate.

i

For Cichon, included in models 2 and 3 was an analysis of 104 BP-I and 24 BP-II cases; the only other analysis included 128 BP-I, 14 SAB, 40 BP-II, 40 RUP, and 23 Other cases and was used here only for model 4.

j

For Curtis, an analysis of 24 BP-I and 15 BP-II cases was included in models 2 and 3; an additional 35 Other cases were included only in model 4.