Figure  3.

Physical map of the FH critical region on 1q42.3 A, Ideogram of human chromosome 1q long arm with some markers at 1q42.3-43, with integrated genetic map (above) and physical map (below), showing locations of selected polymorphic markers. Cent. = centromere; Tel. = telomere. B, Expanded physical map. The BAC tiling path is shown by blue horizontal lines and GenBank clone ID numbers. BAC overlaps were confirmed in silico. A sequence gap is present in the 2.6-Mb region. C, Locations of known genes, shown within the 2.6-Mb region of FH. Seven known genes were identified and confirmed by searching public and private databases. D, FH exon-intron structure and mutations identified in the exonic sequence.