Figure 1.

A, Whole-genome analysis for loci linked with both GD and HT (AITD). The X-axis shows the relative marker positions on each chromosome, and the Y-axis shows the two-point LOD score obtained for each marker on every chromosome. Three loci, on chromosomes 6p, 8q, and 10q (marked by asterisks [*]), gave two-point LOD scores >2. B, The differences between the two-point LOD scores obtained in the expanded data set and those obtained in the original data set. The X-axis shows the relative marker positions on each chromosome, and the Y-axis shows Z_total−Z_orig for each marker. Two loci, on chromosomes 8q and 10q, showed a notable increase in LOD scores. One marker on 2q also showed an increase in LOD score, but the Z_total at this locus remained <2.