TABLE 2.

Examples of animal IBD models

Spontaneously occurring

C3H/HeJBir mouse strain

SAMP1/Yit strain mice

Treatment with mucosal-injuring agents

Trinitrobenzene sulfonic acid (TNBS) enemas

Dextran sulfate sodium (DSS) administration

Alteration of cytokine function

IL-10 knockout mouse

IL-2 knockout mouse

TNF ΔARE mice

STAT-4 transgenic mice

Alteration of T-cell function

T-cell receptor α knockout mouse

T-cell receptor β knockout mouse

HLA-B27 transgenic rat

Transfer of CD4+ CD45RBhi cells into SCID or Rag−/− mice

Impairment of epithelial barrier function

Mutated multidrug-resistant gene mice

Intestinal trefoil factor knockout mice