Table 3.

Multipoint MLSs and Peak Positions in Three Separate Analyses^[Note]

	Updated 110 Familiesa			345 Familiesb			345 Familiesand Fine-Map Markersc
Chromosome	Peak(cM)d	MLS	Pe	Peak(cM)d	MLS	Pe	Peak(cM)d	MLS	Pe
4	94	.713	.054	92	1.72	.0043	94	1.72	.0043
5	0	1.44	.0085	0	.839	.0388	0	.869	.0359
5	59	2.01	.0021	60	1.89	.00285	59	2.54	.00059
8	130	1.71	.0044	132	.84	.0388	132	1.6	.0058
11	53	1.08	.021	46	2.24	.0012	…	…	…
17	49	.633	.0667	52	2.04	.00198	52	2.83	.00029
19	35	3.36	.000085	39	.686	.058	33	.778	.045
X	139	2.27	.0044	99	1.78	.003	…	…	…

Note.— Chromosomal regions with MLS > 1.4 (P < .01) in each analysis are underlined. For clarification and comparison, we show the corrected results of the original 110 families for these regions with the highest MLSs. Chromosomes 11 and X did not have any fine map markers added, so the two analyses of the 345 families are identical.

^aOriginal 110 families reanalyzed with the updated pedigree and phenotype information from AGRE.

^bTotal data set, without the additional high-density fine-map markers; therefore, 335 microsatellite markers covering the genome at 10-cM density.

^cTotal data set and fine-map markers, with all 408 microsatellite markers.

^dPosition of the highest point expressed as distance from pter = 0.

^eTwo-tailed P values were calculated according to methods described by Nyholt (2000).