Figure 6.

The effect of varying marker density on the “coverage” criterion. The simulations assume a population size of N=10,000 and the medium hotspot model (see the “Material and Methods” section for details). The simulated marker density is proportional to the mutation rate parameter θ. The simulations with θ=k are roughly comparable to the sub-Saharan African data from Gabriel et al. (2002), where k=7.836×10^-5/bp. The simulations with θ=8k produce a marker density only slightly lower than would be obtained by complete resequencing in an ascertainment sample of eight chromosomes (Frisse et al. 2001).