Table 1.
Summary of the characterized MNIOs to date.
| MNIO | Organism | Modification | Modified residue | Representative structure(s) (PDB ID) | Pathway |
|---|---|---|---|---|---|
| U.C.a | Haemophilus somnus (Histophilus somni) strain 129pt | Unknown | Unknown | 3BWW (diiron) | Unknown |
| MbnB | Methylosinus trichosporium OB3b, Rugamonas rubra ATCC-43154, Vibrio caribbeanicus ATCC BAA-2122 | Oxazolone-thioamide installation | Cysteine | 7DZ9, 7FC0 (triiron MbnABC complex) | Methanobactin biosynthesis |
| TglH | Pseudomonas syringae pv. maculicola ES4326 | β-carbon excision | Cysteine | 8HCI (apo TglHI) 8HI7 (diiron TglHI) 8HI8 (triiron TglHI) |
3-Thiaglutamate biosynthesis |
| TmoH | Tistrella mobilis KA081020-065 | β-carbon excision | Cysteine | N.A.a | 3-Thiahomoleucine biosynthesis |
| ChrH | Chryseobacterium sp. JM1 | Hydantoin-macrocycle formation | Cysteine | N.A. | Unknown |
| ApyH | Burkholderia thailandensis E264 | Aminopyruvic acid formation | Aspartate | N.A. | Aminopyruvatide biosynthesis |
| MovX (MbnX) | Vibrio fluvalis 33809 | C-terminal amidation via N-C⍺ bond cleavage | Asparagine | N.A. | Unknown |
| BufB | Caulobacter vibrioides NA1000 | 5-thiooxazole installation | Cysteine | N.A. | Bufferin biosynthesis |
a
U.C., uncharacterized; N.A., not available