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Pedigrees and haplotypes. A, Pedigree 1. B, Pedigree 2. C, Pedigree 3. D, Pedigree 4. Affected and unaffected individuals are represented by the blackened and unblackened symbols, respectively. An asterisk (*) indicates individuals who provided blood. Single asterisk (*) and double asterisk (**) indicate members in pedigrees 1, 2, and 3 who were utilized for linkage analysis. E, Haplotype analysis. The shared disease-associated haplotype is colored.
