Table 1.
Biochemical characteristics of the C282Y homozygous patients before and after the implementation of the genetic test.
| Diagnosis based on HFE genotyping | Crude p-value | Adjusted* p-value | ||||
| No | Yes | |||||
| mean | (SD) | mean | (SD) | |||
| No. of patients | 91 | 324 | ||||
| Gender (no. and % of males) | 72 | (79.1%) | 164 | (50.6%) | p < 10-5 | - |
| Males | ||||||
| Serum ferritin (μg/L) | 1886.6 | (1769.7) | 1136.9 | (951.0) | <0.001 | <0.001 |
| Serum iron (μmol/L) | 40.7 | (6.9) | 36.7 | (6.7) | <0.001 | <0.001 |
| Transferrin saturation (%) | 79.9 | (11.9) | 83.0 | (13.2) | 0.090 | 0.134 |
| Females | ||||||
| Serum ferritin (μg/L) | 1418.0 | (1457.9) | 475.7 | (744.6) | <0.001 | <0.001 |
| Serum iron (μmol/L) | 36.6 | (8.2) | 33.1 | (7.4) | 0.052 | 0.029 |
| Transferrin saturation (%) | 77.2 | (13.4) | 75.9 | (14.4) | 0.710 | 0.714 |
* Adjusted for age at diagnosis and alcohol consumption