Figure 5. Measures of anxiety in mepyramine- and zolantidine-treated male wild-type and Apoe^−/− mice in the elevated plus maze.

Compared with saline controls, Apoe^−/− mice that received mepyramine showed significant increases in time spent in the open arms (A), in distance moved in the open arms (B), in the number of extensions over the edges of the open arms (C) and in the rest time in the open arms (D), indicating decreased measures of anxiety after treatment with mepyramine. Wild-type mice showed no significant change in any of these measures of anxiety. None of the differences between wild-type and Apoe^−/− mice were significant. Treatment with zolantidine did not ameliorate measures of anxiety in either genotype. **P<0.01; *P<0.05 compared with saline controls. Wild-type mice, saline control, n=9; mepyramine-treated, n=8; zolantidine-treated, n=8; Apoe^−/− mice, saline control, n=7; mepyramine-treated, n=7; zolantidine-treated, n=5.