TABLE 2.
Interaction of Tat domains with vascular cell surface molecules mediating Tat angiogenic effects
| Effect on endothelial cells | Tat domain involved | Cell surface molecule(s) involved |
|---|---|---|
| Focal adhesion kinase phosphorylationa | RGD | α5β1 and αvβ3 |
| Basic | VEGF receptor 2 | |
| Cysteine rich (participates) | VEGF receptor 2 | |
| Adhesionb | RGD (main mediator) | α5β1 and αvβ3 |
| Basic (participates) | Heparan sulfate proteoglycans | |
| Growthc | Basic (main mediator) | VEGF receptor 2, heparan sulfate proteoglycans |
| Cysteine rich (participates) | VEGF receptor 2? | |
| RGD (participates) | α5β1 and αvβ3 | |
| Migration and/or invasiond | RGD (main mediator) | α5β1 and αvβ3 |
| Basic (participates) | Heparan sulfate proteoglycans, VEGF receptor 2? |
a
See references 70, 123, and 171.
b
See references 16, 17, 54, and 123.
c
See references 4, 16-18, 52-54, 59-61, 123, 127, 138, and 171.
d
See references 2-4, 17, 18, 54, 61, 123, and 171.