Figure 5. Multiple amino acid sequence alignment of BAH domains.
The alignment is subdivided into three groups (indicated by the numerals at the left-hand side of the alignment). Group 1 contains only proximal polybromo-BAH domains, group 2 the polybromo-related proteins RSC1, RSC2 and the transcription factor Ash1, with group 3 containing distal polybromo-BAH domains. Residues conserved within a group are shaded light grey; residues conserved across all groups are boxed and highlighted by a triangle; residues invariant across all groups are shown in white with a black background and further highlighted with a star. Sequence numbering and secondary-structure elements for polybromo-BAH1 are shown. Alignments were generated using Multalin [22].