In the alignment made by the DIALIGN2 program [29], the most conserved regions between the human, mouse, rat, dog and chicken matrilin-1 promoter sequences are shown. The human, mouse and rat matrilin-1 promoter sequence data are from the ENSEMBL database [26], the dog sequence is from the EMBL database (accession no. AACN010934065). Positions are given relative to the TATA box. Asterisks mark the fully conserved nucleotides. Interrupted horizontal arrows above and below the consensus sequence of Dpe1 and Pe1 indicate putative Sox motifs marking those nucleotides that are identical with the consensus L-Sox5/Sox6 and Sox9 recognition sequences respectively shown in a separate box.