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. 2005 Jul 18;102(30):10634–10639. doi: 10.1073/pnas.0500147102

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Copyright © 2005, The National Academy of Sciences

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Fig. 4. — Altered adhesion and transmigration of JAM-A^-/- PMN in vitro. (a) Adhesion of JAM-A^-/- PMN (dashed columns) to endothelial cells expressing or not JAM-A (EC-JAM-A^-/- and EC-JAM-A^+/+, respectively) was significantly increased in comparison with JAM-A^+/+ PMN (black columns). (b) Transmigration of JAM-A^-/- PMN (dashed columns) through both JAM-A-positive and -null endothelial monolayers was decreased as compared with JAM-A^+/+ PMN (black columns). Data represent the percentage of total cells migrated. (c) Adhesion of JAM-A^-/- PMN (dashed columns) to endothelial cells expressing or not ICAM-1 (EC-ICAM-1^-/- and EC-ICAM-1^+/+, respectively) or (d) to fibronectin or laminin was significantly increased in comparison with JAM-A^+/+ PMN (black columns). Results are means ± SEM of data obtained with cells derived from three to six mice. ^*, P < 0.01 vs. JAM-A^+/+ PMN by Student's t test.