Table 1. Transmission disequilibrium test of TLR5 alleles and haplotypes in Caucasian SLE cohort.

		Affected offspring			Unaffected offspring
TLR5 allele(s)	Allele(s)	T/NT	T, %	P value	T/NT	T, %	P value
Allele
C1174T	C	19:6	76.0	0.009	3:6	33.3	NS
A1775G	A	37:26	58.7	0.166	11:11	50.0	NS
T1846C	T	61:57	51.7	0.713	20:22	47.6	NS
A2523G	A	34:26	56.7	0.302	7:9	43.8	NS
Haplotype
1-2	CA	45:22	67.2	0.005	11:14	44.0	NS
	TA	4:17	19.0	0.005	5:3	62.5	NS
1-2-3	CAC	48:29	62.3	0.030	15:14	51.7	NS
	TAC	3:14	17.6	0.008	4:1	80.0	NS
1-2-3-4	CACA	48:29	62.3	0.030	15:14	51.7	NS
	TACA	3:14	17.6	0.008	4:1	80.0	NS

Data presented are derived from TLR5 alleles transmitted and not transmitted from heterozygous parents to offspring in 199 Caucasian families. Data represent families that had complete genotyping data available for both parents and the affected or unaffected offspring. Data are shown as the percentage transmission (T) of each allele. The P value for each allele is the level of significance based on the deviation from the expected random (50%) allele transmission and was evaluated by using a χ² statistic. NS, not significant.