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. 2005 Jul 15;102(30):10454–10459. doi: 10.1073/pnas.0504786102

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Copyright © 2005, The National Academy of Sciences

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Fig. 9. — Effects of alkaline phosphatase treatment or mutation on human MTHFR activity. The NADPH-menadione oxidoreductase assay was used to measure activity after preincubation of the enzyme with 100 μM NADPH and AdoMet at the indicated concentration. (A) Effect of alkaline phosphatase treatment on the activity of purified wild-type and Thr34Ala human MTHFR. (B) Effect of alkaline phosphatase treatment and/or mutation of Thr34Ala on inhibition of NADPH-menadione oxidoreductase activity by AdoMet. Shown are wild-type MTHFR with (•) or without (○) alkaline phosphatase treatment and Thr34Ala mutant MTHFR with (▪) or without (□) alkaline phosphatase treatment.