Table 1.
KEGG pathways enriched in pituitaries of juvenile female Atlantic cod treated with BPA and EE2.
| Term | Adjusted P-value | Genes |
|---|---|---|
| cAMP signaling pathway | 3.9E-03 | abcc4, grin3a, pln, creb3l3a, fshb, pde4c, pde3a, cga, tshba |
| Neuroactive ligand-receptor interaction | 3.9E-03 | p2ry13, grin3a, galr1a, fshb, chrna9, gnrhr4, tacr2, cga, adra1aa, tshba, rxfp3 |
| Calcium signaling pathway | 4.1E-03 | fgf8a, pln, gdnfa, erbb3a, tacr2, itpr3, plcd3a, adra1aa, camk1ga |
| Dopaminergic synapse | 1.5E-02 | ddc, creb3l3a, gng8, itpr3, gnb5a, kcnj3a |
| GnRH signaling pathway | 1.5E-02 | egr1, fshb, gnrhr2a, itpr3, cga |
| PI3K-Akt signaling pathway | 2.1E-02 | kitlga, fgf8a, creb3l3a, erbb3a, myca, gng8, gnb5a, itgb6, pgfb |
| Serotonergic synapse | 2.1E-02 | ddc, gng8, itpr3, gnb5, kcnj3a |
| Cholinergic synapse | 2.1E-02 | creb3l3a, gng8, itpr3, gnb5a, kcnj3a |
| MAPK signaling pathway | 2.1E-02 | dusp5, kitlga, fgf8a, erbb3a, myca, taok1b, cacng3, pgfb |
| Glutamatergic synapse | 2.1E-02 | grin3a, gng8, itpr3, gnb5a, kcnj3a |
| Ras signaling pathway | 2.1E-02 | shc4, kitlga, fgf8a, gng8, rasal1b, gnb5a, gab |
| Chemical carcinogenesis | 2.3E-02 | ar, fgf8a, creb3l3a, myca, chrna9, pgr, sult1st4 |
| Thyroid hormone synthesis | 2.5E-02 | creb3l3a, itpr3, cga, tshba |
| Relaxin signaling pathway | 2.7E-02 | shc3, creb3l3a, gng8, gnb5a, rxfp3 |
| Apelin signaling pathway | 3.2E-02 | egr1, gng8, itpr3, gnb5a, prkag3b |
| Estrogen signaling pathway | 3.2E-02 | shc4, creb3l3a, pgr, itpr3, kcnj3a |
| Hypertrophic cardiomyopathy | 3.8E-02 | lmna, itgb6, cacng3, prkag3b |
| Retrograde endocannabinoid signaling | 3.9E-02 | ndufv1, gng8, itpr3, gnb5a, kcnj3a |
| Oxytocin signaling pathway | 3.9E-02 | itpr3, cacng3, prkag3b, camk1ga, kcnj3a |
| Circadian entrainment | 3.9E-02 | gng8, itpr3, gnb5a, kcnj3a |
| Ovarian steroidogenesis | 4.1E-02 | fshb, cga, cyp19a1b |
| Parathyroid hormone synthesis, secretion and action | 4.8E-02 | egr1, creb3l3, pde4c, itpr3 |
| cGMP-PKG signaling pathway | 4.8E-02 | pln, creb3l3, pde3a, itpr3, adra1aa |
| Tight junction | 4.9E-02 | rab13, arhgef18b, prkag3b, tjp2 |
KEGG pathway enrichment analysis was performed using DEGs shared between BPA (40 or 200 μmol/kg bw) and EE2 (50 or 250 nmol/kg bw) using Enrichr (58). The expression profile of the top shared DEGs is shown in Figure 2 . The genes populating the KEGG pathways are shown in red and light green colored fonts, for upregulated and downregulated genes, respectively.