Figure 1. Extravasation of protein-rich plasma to the interstitial space, leads to the 3 “H’s” of ISCLS: hypotension, hemoconcentration and hypoalbuminemia.

Created in BioRender by Vasileios Patriarcheas (https://BioRender.com/t82m862)

ISCLS: Idiopathic systemic capillary leak syndrome