1. Gently remove all dressing and clean the wound through abundant irrigation with a standard saline solution, finalizing by irrigation with a non‐cytotoxic antimicrobial solution. Eventually, clean the wound gently with a gauze embedded with this product

2. Check the integrity of the L‐PRF membranes. Those that are attached to the wound surface or those that are becoming granulation‐type tissue should not be removed

3. Loose L‐PRF membranes, necrotic tissue, and eschar, however, should be removed

4. Repeat steps 4 to 10 (see previous page), avoiding any unnecessary or profound debridement

5. Repeat this procedure weekly until complete coverage of the wound with healthy epithelium. At the end of the treatment, longer time intervals (e.g. 2 weeks) can be taken into consideration The need for painkillers should reduce significantly after the first applications of the L‐PRF membranes The bad smell of the wound should be replaced by the typical smell of using L‐PRF membranes