✓ Before any intervention of the wound, its etiology should be identified, and a causal therapy should be started!

✓ It can be useful to measure and record the length, width, and depth of the wound. Pictures of the wound with a reference (e.g., measuring rod ruler, millimeter paper) can be useful to follow the evolution of the wound

✓ All chronic wounds have a biofilm and are contaminated with different bacteria. Any signs of infection should be taken into consideration!

✓ It is advisable to run a bacterial culture from the wound before the start of the L‐PRF therapy!

To reduce the chance of major wound infection it is suggested to: Prepare a sterile drape around the wound, Use surgical gloves and a surgical mask, and To disinfect not only the wound but also the area around the wound to prevent transmission of infection from this area to the wound