✓ All chronic wounds are contaminated with different bacteria. Wound infections during the L‐PRF treatment are, however, rare!

✓ When the first signs of infection are seen, an even more thorough disinfection should be undertaken via, for example, the application of a gauze embedded with a non‐cytotoxic antimicrobial solution to the infected area for several minutes

✓ When applying the L‐PRF membranes, make sure that the face of the membranes (the red part of the membrane that initially was in contact with the red blood cells) is applied towards the suspected area. The leukocytes in the face area can, as such, more easily reach the infection.

✓ Antibiotic therapy is not recommended unless a major infection is observed. Specific systemic antibiotics should be given concomitantly with the L‐PRF therapy, based on the outcome of a bacterial culture!