Table 1.

Mutual dilutional effect of blood components in different combinations. As a patient severely bleeds and continuously receives one of the associations above, the levels of blood elements progressively assume the hematologic profile of the final reconstituted product. This way, theoretically, a patient who had its whole blood volume substituted by one of the combinations above would acquire the concentrations shown above. By assuming the final product adequation criteria specified in the article, values highlighted in bold show insufficient levels, whereas those in italic demonstrate unpurposely high levels. Definitions, characteristics of blood components and formulas used to generate this table are available in supplementary material, including the possibility of simulating results with other characteristics or combinations.

Combinations					Hematologic profile of the final reconstituted product
FFP	PC	RBC	Cryo	Fluids(mL)	FactorsConc.(%)	Ht(%)	Plt(/µL)	Fib(mg.dL−1)
1	1	1	0	0	60	28	88.000	164
1	1	2	0	0	50	37	57.895	137
1	1	3	0	0	44	42	43.137	121
1	2	1	0	0	62	26	162.963	169
2	1	1	0	0	67	20	62.857	183
2	2	1	0	0	68	19	118.919	185
1	2	2	0	0	53	36	110.000	143
1	1	1	1	0	58	28	85.938	213
1	1	2	1	0	49	37	56.995	175
1	1	1	0	500	28	16	48.889	77

FFP, Units of Fresh Frozen Plasma; PC, Units of Platelet Concentrates (single); RBC, Units of Red Blood Cells Concentrates; Cryo, Units of Cryoprecipitate; FactorsConc.: Final percent of clotting factors in comparison with the concentration of the original donated plasma; Ht, Hematocrit; Plt, Platelet count; Fib, Fibrinogen level.