Table 3.
Correlation of change in FACIT-F with change in clinical measures.
| Clinical measure | Week 12 (N = 191) |
Week 52 (N = 176) |
Week 104 (N = 137) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Pearson corr | 95% CI | P | Pearson corr | 95% CI | P | Pearson corr | 95% CI | P | |
| CDAI total score | −0.404 | (−0.530, −0.259) | <0.0001 | −0.492 | (−0.614, −0.346) | <0.0001 | −0.465 | (−0.604, −0.300) | <0.0001 |
| Hematocrit (%) | −0.039 | (−0.194, 0.119) | 0.6319 | 0.152 | (−0.016, 0.312) | 0.0756 | 0.109 | (−0.074, 0.284) | 0.2426 |
| Hemoglobin | −0.011 | (−0.167, 0.145) | 0.8916 | 0.120 | (−0.049, 0.282) | 0.1638 | 0.129 | (−0.053, 0.303) | 0.1640 |
| Fecal calprotectin (log) | −0.269 | (−0.419, −0.105) | 0.0015 | −0.175 | (−0.342, 0.003) | 0.0544 | −0.155 | (−0.336, 0.038) | 0.1155 |
| C-reactive protein (log) | −0.165 | (−0.310, −0.013) | 0.0331 | −0.151 | (−0.310, 0.016) | 0.0756 | −0.275 | (−0.433, −0.100) | 0.0024 |
| Abdominal pain average score | −0.380 | (−0.504, −0.240) | <0.0001 | −0.438 | (−0.565, −0.292) | <0.0001 | −0.352 | (−0.506, −0.176) | 0.0001 |
| Stool frequency average score | −0.354 | (−0.481, −0.212) | <0.0001 | −0.290 | (−0.437, −0.128) | 0.0006 | −0.338 | (−0.494, −0.161) | 0.0003 |
| SES-CD total score | −0.146 | (−0.290, 0.004) | 0.0572 | −0.076 | (−0.238, 0.090) | 0.3702 | |||
Abbreviations: CDAI, Crohn’s Disease Activity Index; corr, correlation; N, number of patients in the analysis (including patients with nonmissing change scores); FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; SES-CD, Simplified Endoscopic Activity Score for Crohn’s Disease. A negative correlation indicates an improvement in outcome is associated with an improvement in FACIT-F.