Table 3.

Multivariate logistic regression models with interactions, where Odds ratio>1.0 favours BRCA testing.

Diagnosis year	2000–2005	2006–2011		2012–2017		P
Age at diagnosis1		Odds ratio	[95% CI]	Odds ratio	[95% CI]	< 0.0001
18–39	Ref	2.75	[2.21–3.41]	4.78	[3.77–6.07]
40–59	Ref	0.71	[0.65–0.78]	1.06	[0.97–1.16]
≥ 60	Ref	0.79	[0.68–0.93]	0.96	[0.82–1.13]
ER/HER22		Odds ratio	[95% CI]	Odds ratio	[95% CI]	< 0.0001
ER-/HER2-	Ref	1.48	[1.22–1.78]	3.63	[3.00–4.38]
ER-/HER2+	Ref	1.28	[0.99–1.67]	1.83	[1.38–2.45]
ER+/HER2-	Ref	0.71	[0.71–0.97]	0.87	[0.80–0.96]
ER+/HER2+	Ref	0.93	[0.81–1.21]	1.25	[1.03–1.54]
Unknown	Ref	2.16	[1.75–2.66]	1.79	[1.05–3.05]

CI: confidence interval.

¹Odds ratios for the interaction term of age at diagnosis and diagnosis year in multivariate LR model, adjusted for region of residency and receptor status;

²Odds ratios for the interaction term of receptor status and diagnosis year in the multivariate LR model, adjusted for region of residency and age at diagnosis.