Fig. 2.

Schematic representation of the preclinical models of hematopoietic stem cell transplantation (HSCT). A In congenic HSCT, hematopoietic stem cells (HSCs) are collected from the bone marrow (BM) of the femur and/or the tibia of donor C57BL/6 CD45.2 mice. HSCs are then intravenously injected into recipient C57BL/6 CD45.1 congenic mice, which are preconditioned by irradiation or chemotherapy. B In allogeneic HSCT, HSCs are collected from the femur and/or the tibia of donor C57BL/6 mice. HSCs are then intravenously injected into recipient BALB/c mice, which are preconditioned by irradiation or chemotherapy. C–D In xenogeneic HSCT, human HSCs are obtained from the cord blood, the mobilized peripheral blood, or the bone marrow of a donor human patient. HSCs are then intravenously injected into recipient immune-deficient mice (C: irradiated NSG mice and D: NBSGW mice)