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. 2025 Feb 10;12(6):2570031. doi: 10.1002/advs.202570031

Engineered Mesenchymal Stem Cell‐Derived Extracellular Vesicles Scavenge Self‐Antigens for Psoriasis Therapy via Modulating Metabolic and Immunological Disorders (Adv. Sci. 6/2025)

Xin Zhou, Bo Tang, Qing Huang, Siyu Yang, Yang Jiang, Lizhou Xu, Wen Chen, Guangchang Shan, Xuankai Liao, Chongchao Hou, Zhihong Yao, Chaowei Zou, Rongying Ou, Yunsheng Xu, Danyang Li
PMCID: PMC11809320

Abstract

Novel Therapy for Psoriasis

In article number 2410067, Xin Zhou, Yunsheng Xu, Danyang Li, and co‐workers present a novel engineered mesenchymal stem cell‐derived extracellular vesicles for treating psoriasis, a condition currently lacks a complete cure. This approach can effectively reduce psoriasis‐specific self‐antigens and modulate both metabolic and immunological disorders, thereby providing new insights for psoriasis therapy.

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