Table 1.
Summary of the expression and functions of circRNAs in non-small cell lung cancer
| circRNA | Expression pattern | Biomarker category | Key factors/pathway | Function | References |
|---|---|---|---|---|---|
| circ-ITCH | Down-regulation | Therapeutic target | miR-7/miR-214/Wnt/β-catenin pathway | Inhibits cell proliferation | Wan et al. (2016) |
| circ_001569 | Upregulation | Therapeutic target | Wnt/β-catenin pathway | Promotes cell proliferation; its upregulation is associated with tumor differentiation, lymph node metastasis, advanced TNM stage, and shorter overall survival | Ding et al. (2018) |
| circ_008305 (circPTK2) | Down-regulation | Therapeutic target | miR-429/miR-200b-3p/TIF1γ/TGF-β-induced EMT | Inhibits cell invasion and metastasis | Wang et al. (2018b) |
| circ-0008717 (circABCB10) | Upregulation | Prognosis/therapeutic target | miR-1252/FOXR2 axis | Promotes cell proliferation, migration, and tumor growth | Tian et al. (2019) |
| cicc_0016760 | Upregulation | Therapeutic target | miR-1287/GAGE1 axis | Promotes cell proliferation, migration invasion and inhibits cell apoptosis; its upregulation is associated with advanced TNM stages, lymph node metastasis, and shorter overall survival | Li et al. (2018d) |
| circ_Foxo3 | Down-regulation | Diagnosis/therapeutic target | miR-155/Foxo3 gene; circ-Foxo3-p21-CDK2 ternary complex | Inhibits cell proliferation, migration, and invasion, and promotes apoptosis; arrests cell in G1/S phase | Zhang et al. (2018d), Du et al. (2016) |
| circ_0046264 | Down-regulation | Therapeutic target | miR-1245/BRCA2 | Inhibits cell proliferation, invasion, and tumor growth; promotes apoptosis | Yang et al. (2018) |
| circ_0001649 | Down-regulation | Prognosis/therapeutic target | miR-331-3p/miR-338-5p | Inhibits cell proliferation, migration, invasion, and tumor growth; its down-regulation is associated with advanced TNM stage, positive lymph node metastasis and poor prognosis | Liu et al. (2018a) |
| circ_0000729 | Upregulation | Diagnosis/prognosis | miR-375 | Its overexpression is associated with advanced T stage and distant metastasis | Li et al. (2018b) |
| circ_0007385 | Upregulation | Therapeutic target | miR-181 | Promotes cell proliferation, migration, invasion, and tumor growth | Jiang et al. (2018) |
| circ_0020123 | Upregulation | Prognosis/therapeutic target | miR-144-ZEB1/EZH2 | Promotes cell proliferation, migration, invasion, and tumor growth, metastasis; its upregulation is associated with poor differentiation, lymph node metastasis, advanced TNM stage, and poor prognosis | Qu et al. (2018) |
| circ_BANP | Upregulation | Prognosis/therapeutic target | miR-503-LARP1 | Promotes proliferation, migration, invasion, and inhibit apoptosis; its upregulation is associated with advanced TNM stage, lymph node metastasis, and poor prognosis | Han et al. (2018) |
| circ_0014130 | Upregulation | Diagnosis | Its upregulation is associated with advanced TNM stage and lymph node metastasis | Zhang et al. (2018b) | |
| circ_0033155 | Down-regulation | Diagnosis | PTEN | Inhibits cell proliferation, colony formation, and migration; its down-regulation is associated with lymph node metastasis | Gu et al. (2018) |
| circ_0067934 | Upregulation | Prognosis/therapeutic target | Promotes cell proliferation; its upregulation is associated with lymph node metastasis, advanced TNM stage, and poor overall survival | Zou et al. (2018) | |
| circ_0007534 | Upregulation | Prognosis/therapeutic target | EMT pathway | Promotes cell proliferation, migration, invasion, tumor growth and inhibits cell apoptosis; its upregulation is associated with advanced TNM stage, lymph node metastasis, and poor overall survival | Qi et al. (2018) |
| circ_0003998 | Upregulation | Prognosis/therapeutic target | miR-326/Notch1 | Its upregulation is associated with larger tumor size, lymph node metastasis, and poor overall survival | Yu et al. (2018b) |
| circ_0000064 | Upregulation | Diagnosis/prognosis | Promotes cell proliferation, migration, invasion, and inhibits apoptosis; regulates cell-cycle progression; its upregulation is associated with lymph node metastasis and TNM stage | Luo et al. (2017) | |
| circ_0013958 | Upregulation | Diagnosis | miR-134/cyclin D1 | Promotes cell proliferation, migration, invasion, and inhibits cell apoptosis; its upregulation is associated with lymph node metastasis and TNM stage | Zhu et al. (2017) |
| circ_0043256 | Upregulation | Therapeutic target | miR-1252/ITCH/Wnt/β-catenin pathway | Inhibits cell proliferation and promotes apoptosis; is involved in response to Cinnamaldehyde treatment | Tian et al. (2017) |
| circ_100833(FADS2) | Upregulation | Prognosis/therapeutic target | miR-498 | Promotes cell proliferation, migration and invasion; its upregulation is associated with advanced TNM stage, lymph node metastasis, poor differentiation, and poor overall survival | Zhao et al. (2018) |
| circ_100395 | Down-regulation | Diagnosis/prognosis | miR-1228/TCF21 pathway | Inhibits cell proliferation, migration, invasion, and tumor growth; arrests cells in G0/G1 phase; its down-regulation is associated with advanced TNM stage, lymph node metastases, and poor overall survival | Chen et al. (2018) |
| circ_0075930 | Upregulation | Prognosis/therapeutic target | EMT | Promotes G0/G1-phase to S-phase transition; its upregulation is associated with tumors size and lymph node metastasis | Li et al. (2018a) |
| circ_FARSA | Upregulation | Diagnosis | miR-330-5p/miR-326 FASN (fatty acid synthase) | Promotes cell migration and invasion | Hang et al. (2018) |
| circ_103595(MAN2B2) | Upregulation | Therapeutic target | miR-1275/FOXK1 | Promotes cell proliferation and invasion | Ma et al. (2018) |
| circ_102231 | Upregulation | Diagnosis/therapeutic target | Promotes cell proliferation and invasion; its upregulation is associated with advanced TNM stage, lymph node metastasis, and poor overall survival | Zong et al. (2018) | |
| circ_103809 | Upregulation | Prognosis | miR-4302/ZNF121/MYC | Promotes cell proliferation, invasion and tumor growth; its upregulation is associated with poor overall survival | Liu et al. (2018a, b) |
| ciRS-7/(CDR1as) | Upregulation | Prognosis | miR-7/EGFR/CCNE1/PIK3CD | Promotes cell proliferation and inhibits cell apoptosis; its upregulation is associated with lymph node metastasis, advanced TNM stage, and shorter overall survival | (Zhang et al. 2018c) |
| circ_0001346 (RNF13) | Down-regulation | Prognosis/therapeutic target | miR-93-5p | Inhibits cell migration and invasion; its down-regulation is associated with lymph node metastasis and TNM stage | Wang et al. (2018a) |
| circ_0067934 | Upregulation | Prognosis/therapeutic target | EMT | Promotes cell proliferation, migration and invasion; its upregulation is associated with lymph node metastasis, distant metastasis, advanced TNM stage, and poor overall survival | Wang and Li (2018) |
| circ_100876 (CER) | Upregulation | Prognosis | Its upregulation is associated with lymph node metastasis, TNM stage, and shorter overall survival | Yao et al. (2017) | |
| circ_0067934 (PRKCI) | Upregulation | Prognosis/therapeutic target | miR-545/miR-589-E2F7 | Promotes cell proliferation, migration and tumor growth; its upregulation is associated with advanced TNM stage and shorter overall survival | Qiu et al. (2018) |
| Circ-UBR5 | Down-regulation | Prognosis | QKI, NOVA1, U1 snRNA/spliceosome-mediated RNA-splicing regulation | Inhibits cell differentiation | Qin et al. (2018) |
| circ_0006916 | Down-regulation | Therapeutic target | miR-522-3p/PHLPP1 | Inhibits cell proliferation; inhibits G1-phase to S-phase transition | Dai et al. (2018) |
| circ_0012673 | Upregulation | Therapeutic target | miR-22/ErbB3 | Promotes cell proliferation and tumor growth; its upregulation is associated with tumor size | Wang et al. (2018c) |
| F-circEA-4a | Diagnosis/therapeutic target | Promotes cell migration and invasion | Tan et al. (2018a) | ||
| F-circEA-2a | Promotes cell migration and invasion | Tan et al. (2018b) |