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Dose-response relationships for protective activity of androsterone (5α,3α-A) and its 5β- and 3β-epimers in the 6 Hz electrical stimulation model (A) and the pentylenetetrazol (PTZ) model (B). Steroids were administered 15 min before electrical stimulation or injection of PTZ (see Methods). Data points indicate percentage of animals protected. Each point represents 6 to 8 mice.
