Figure 5.

Role of MKK6 as a therapeutic target in NSCLC cells. (A) MKK6 expression levels in lung adenocarcinoma and lung squamous cell carcinoma cells, based on data obtained from the TCGA database. (B) Prognostic significance of MKK6 expression in lung cancer, analyzed using the Kaplan-Meier plotter. (C) Efficacy of MKK6 knockdown, determined using Western blotting. (D) Effect of MKK6 knockdown on NSCLC cell growth, determined using the MTT assay. (E) Effect of MKK6 knockdown on focus formation in NSCLC cells. Cells were incubated for 1 week, and the number of foci was counted. For (D and E), data are shown as means ± SD values derived from three independent experiments. Asterisks (**, ***) indicate significant (P < 0.01, P < 0.001) differences.