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. 2005 Aug 2;3(9):e274. doi: 10.1371/journal.pbio.0030274

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Copyright: © 2005 Fraser et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The abbreviations used are as follows: ACC, anterior cingulate cortex; C, cerebellum; PFC, prefrontal cortex.

(A) Correlations of aging gene expression patterns between all three possible pairs of the three regions of the chimpanzee brain used in this work (from left to right, number of genes used are 1,343, 2,235, and 1,328). The strong correlation when comparing cortex regions indicates a reproducible pattern of aging in chimpanzee cortex.

(B) Correlations of aging gene expression patterns between human frontal pole [7] and each of the three regions of the chimpanzee brain used in this work (841 genes used in each comparison). The lack of any significant correlation suggests that human and chimpanzee brain aging patterns differ.