Quantitative detection of intracellular (filled circles) and extracellular (empty diamonds) HHV-6 DNA at 3 h and 1, 3, 5, and 7 days postinfection of HPDA and SupT-1 cells. While both viral variants (U1102 and Z29) establish a productive infection in SupT-1 cells, only infection with U1102 is productive in HPDA. Intracellular DNA is expressed as viral copies/106 cells; extracellular DNA is expressed as viral copies/milliliter ± standard error of the mean of triplicate values. I, inoculum.