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Immunogenicity of low doses of rAd5, rAd35, and rAd11. Naïve mice were immunized with (A) 108 vp or (B) 107 vp rAd5-Gag, rAd35-Gag, rAd11-Gag, or a sham vector control. Gag-specific CD8+ T-lymphocyte responses were assessed by Db/AL11 tetramer binding assays. The rAd5-Gag responses are depicted in the open circles.
